PTSD Archives - The American Institute of Stress https://www.stress.org/category/ptsd/ Tue, 03 Jun 2025 14:59:39 +0000 en-US hourly 1 https://wordpress.org/?v=6.8.2 June is PTSD Awareness Month-What is Posttraumatic Stress Disorder (PTSD)? https://www.stress.org/news/june-is-ptsd-awareness-month-what-is-posttraumatic-stress-disorder-ptsd/?utm_source=rss&utm_medium=rss&utm_campaign=june-is-ptsd-awareness-month-what-is-posttraumatic-stress-disorder-ptsd Wed, 11 Jun 2025 14:48:28 +0000 https://www.stress.org/?post_type=news&p=111413

Posttraumatic stress disorder (PTSD) is a psychiatric condition that may occur in people who have experienced or witnessed a traumatic event or series of traumatic events. The individual often experience the event or events as emotionally or physically harmful or life-threatening. Examples include, but are not limited to, abuse (physical, sexual, emotional), natural disasters, serious accidents, terrorist acts, war/combat exposure, intimate partner violence, and medical illness. However, most individuals who experience traumas do not go on to develop PTSD.

Many people who are exposed to a traumatic event experience symptoms similar to PTSD in the days following the event. However, for a person to be diagnosed with PTSD, symptoms must last for more than a month and must cause significant distress or problems in the individual’s daily functioning. Many individuals develop symptoms within three months of the trauma, but symptoms may appear later and often persist for months and sometimes years. PTSD often occurs with other related conditions, such as depression, substance use, memory problems and other physical and mental health problems.

PTSD can occur in anyone of any ethnicity, nationality or culture, and at any age. The prevalence of PTSD in the U.S. is estimated to be approximately 4% of U.S. adults and 8% of U.S. adolescents aged 13-18. The lifetime prevalence in the U.S. is estimated to be 6%. PTSD risk factors include:

  • Prior history of trauma (and the severity and frequency of events; perceived lack of support following event(s))
  • Childhood adversity/trauma
  • Female gender
  • Member of a marginalized group (such as non-white, LGBTQ+, living with a disability)
  • Immigrant status

Symptoms and Diagnosis

Symptoms of PTSD fall into four categories. Specific symptoms can vary in severity.

  1. Intrusion: Intrusive (unwanted and involuntary) thoughts such as repeated memories, distressing dreams, or flashbacks of traumatic events. Flashbacks may be so vivid that people feel they are reliving the traumatic experience or seeing it before their eyes and may cause significant fear and panic. These memories and/or nightmares may be triggered by something that reminds the individual of the traumatic event or may be spontaneous.
  2. Avoidance: Avoiding reminders of the traumatic event(s) may include avoiding people, places, activities, objects, and situations that may trigger distressing memories. People may try to avoid remembering or thinking about the traumatic event. Additionally, they may resist talking about what happened or how they feel about it. Oftentimes, these behaviors lead to dysfunction in everyday life.
  3. Changes in cognition and mood: Individuals with PTSD may initially present with depressive symptoms. These include low mood (feeling sad), inability to feel happiness, and a lack of interest in activity and/or people that they used to enjoy. Additionally, individuals with PTSD may have trouble with memory; maybe be unable to remember important aspects of the traumatic event have negative thoughts and feelings leading to ongoing and distorted beliefs about themself or others (e.g., “I am bad,” “No one can be trusted”); have distorted thoughts about the cause or consequences of the event leading to wrongly blaming self or other; have ongoing fear, horror, anger, guilt or shame; have much less interest in activities previously enjoyed; feel detached or estranged from others; or be unable to experience positive emotions (a void of happiness or satisfaction).
  4. Changes in arousal and reactivity: People with PTSD may describe being irritable and having angry outbursts, behaving recklessly or in a self-destructive way, being overly watchful of their surroundings in a suspecting way, being easily startled, or having problems concentrating or sleeping.

Dissociation

Some individuals with PTSD will have the dissociative symptoms:

  • Derealization – The feeling that life is not real. Individual may describe feeling like they are in a movie or in a dream.
  • Depersonalization – The feeling that one is outside of their body.

These symptoms are not required for a PTSD diagnosis and can vary in intensity across the PTSD illness.

The four tabs below provide brief descriptions of four conditions related to PTSD:  acute stress disorder, adjustment disorder, disinhibited social engagement disorder, and reactive attachment disorder.

Treatment

It is important to note that not everyone who experiences trauma develops PTSD, and not everyone who develops PTSD requires psychiatric treatment. For some people, symptoms of PTSD subside or disappear over time. Others get better with the help of their support system (family, friends or clergy). But many people with PTSD need professional treatment to recover from psychological distress that can be intense and disabling. It is important to remember that trauma may lead to severe distress. That distress is not the individual’s fault, and PTSD is treatable. The earlier a person gets treatment, the better chance of recovery.

Psychiatrists and other mental health professionals use various effective and research-proven methods to help people recover from PTSD. Both talk therapy (psychotherapy) and medication provide effective evidence-based treatments for PTSD.

Cognitive Behavioral Therapy

One category of psychotherapy, cognitive behavior therapies (CBT), is very effective. Cognitive processing therapy, prolonged exposure therapy and stress inoculation therapy (described below) are among the types of CBT used to treat PTSD.

  • Cognitive Processing Therapy is an evidence-based, cognitive behavioral therapy designed specifically to treat PTSD and comorbid symptoms. It focuses on changing painful negative emotions (such as shame, guilt, etc.) and beliefs (such as “I have failed;” “the world is dangerous”) due to the trauma. Therapists help the person confront such distressing memories and emotions.
  • Prolonged Exposure Therapy uses repeated, detailed imagining of the trauma or progressive exposures to symptom “triggers” in a safe, controlled way to help a person face and gain control of fear and distress and learn to cope. For example, virtual reality programs have been used to help war veterans with PTSD re-experience the battlefield in a controlled, therapeutic way.
  • Trauma Focused Cognitive Behavioral Therapy is an evidence-based treatment model for children and adolescents that incorporates trauma-sensitive interventions with cognitive behavioral, family, and humanistic principles and techniques.
  • Eye Movement Desensitization and Reprocessing for PTSD is a trauma-focused psychotherapy which is administered over approximately three months. This therapy helps a person to reprocess the memory of the trauma so that it is experienced in a different way. After a thorough history is taken and a treatment plan developed the therapist guides the patient through questions about the traumatic memory. Eye movements similar to those in REM sleep is recreated during a session by having the patient watch the therapist’s fingers go back and forth or by watching a light bar. The eye movements last for a brief time period and then stop. Experiences during a session may include changes in thoughts, images, and feelings. After repeated sessions  the memory tends to change and is experienced in a less negative manner.
  • Group therapy encourages survivors of similar traumatic events to share their experiences and reactions in a comfortable and non-judgmental setting. Group members help one another realize that many people would have responded the same way and felt the same emotions. Family therapy may also help because the behavior and distress of the person with PTSD can affect the entire family.

Other psychotherapies such as interpersonal, supportive and psychodynamic therapies focus on the emotional and interpersonal aspects of PTSD. These may be helpful for people who do not want to expose themselves to reminders of their traumas.

Often individuals will explore various psychotherapy options to find the right fit for them. Additionally, individuals may transition from one therapy to another during their treatment. There is no significant evidence that one psychotherapy is more effective than another. Thus, the decision about which psychotherapy to use should be individualized to each patient.

Medication

Medication can help to control the symptoms of PTSD. In addition, the symptom relief that medication provides allows many people to participate more effectively in psychotherapy.

SSRIs and SNRIs (antidepressants) are commonly used to treat the core symptoms of PTSD and co-occurring mood symptoms. They are used either alone or in combination with psychotherapy or other treatments.

Prazosin, a blood pressure medication, is often prescribed to help with sleep issues related to nightmares in people owith PTSD.

People with PTSD may experience hallucinations that cause significant distress. They may be prescribed antipsychotic medications. These medications may also help with mood, anxiety, and sleep.

There is ongoing research examining the use of psychedelics such as psylocibin and MDMA to treat PTSD. They are typically used along with psychotherapy under the care of a trained professionals in a controlled setting. Currently, there is no FDA-approval for psychedelics to treat PTSD.

Other Treatments

Other treatments including complementary and alternative therapies are also increasingly being used to help people with PTSD. These approaches provide treatment outside the conventional mental health clinic and may require less talking and disclosure than psychotherapy. Examples include acupuncture, yoga and animal-assisted therapy.

In addition to treatment, many people with PTSD find it very helpful to share their experiences and feelings with others who have similar experiences, such as in a peer support group.

Physician Review Donald Egan, M.D. March 2025

 

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In 2025, June is designated as PTSD Awareness Month. https://www.stress.org/news/in-2025-june-is-designated-as-ptsd-awareness-month/?utm_source=rss&utm_medium=rss&utm_campaign=in-2025-june-is-designated-as-ptsd-awareness-month Fri, 06 Jun 2025 14:33:25 +0000 https://www.stress.org/?post_type=news&p=111409

Post-Traumatic Disorder – What is PTSD?

Post-traumatic stress disorder (PTSD) is a real disorder that develops when a person has experienced or witnessed a scary, shocking, terrifying, or dangerous event. These stressful or traumatic events usually involve a situation where someone’s life has been threatened or severe injury has occurred. Children and adults with PTSD may feel anxious or stressed even when they are not in present danger.

Causes

You can get PTSD after living through or seeing a traumatic event, such as war, a natural disaster, sexual assault, physical abuse, or a bad accident. PTSD makes you feel stressed and afraid after the danger is over. It affects your life and the people around you.

PTSD starts at different times for different people. Signs of PTSD may start soon after a frightening event and then continue. Other people develop new or more severe signs months or even years later. PTSD is often related to the seriousness of the trauma, whether the trauma was repeated or not, what the individual’s proximity to the trauma was, and what their relationship is with the victim or perpetrator of the trauma.

To be considered for PTSD, signs and symptoms must last more than a month and be severe enough to interfere with school, work, or relationships. PTSD can happen to anyone, even children.

Signs & Symptoms

Symptoms of PTSD may last months to years. PTSD symptoms may include:

  • Flashbacks, or feeling like the event is happening again
  • Trouble sleeping or nightmares
  • Feeling alone or detached from others
  • Losing interest in activities
  • Having angry outbursts or other extreme reactions
  • Feeling worried, guilty, or sad
  • Frightening thoughts
  • Having trouble concentrating
  • Having physical pain like headaches or stomach aches
  • Avoidance of memories, thoughts, or feelings about what closely associated with traumatic events
  • Problems remembering
  • Negative beliefs about themselves or others
  • Irritability
  • Feeling very vigilant
  • Startling easily

Symptoms of anxiety, depression, and substance use also are seen with people who have PTSD.

Testing for PTSD

According to the National Institute of Mental Health, a doctor who has experience helping people with mental illnesses, such as a psychiatrist or psychologist, can diagnose PTSD.

Get Help

There are several ways someone can manage PTSD. Talking to a specially trained doctor or counselor helps many people with PTSD. This is called talk therapy. Medicines can help you feel less afraid, tense, and depressed. It might take a few weeks for them to work.

Learn how to talk about mental health to help you speak to a loved one who you may think is experiencing any mental health concerns.

Need Help?

  • If you or someone you know is struggling or in crisis, help is available. Call or text 988 or chat 988lifeline.org.
  • To learn how to get support for mental health, drug, and alcohol issues, visit FindSupport.gov.
  • To locate treatment facilities or providers, visit FindTreatment.gov or call SAMHSA’s National Helpline at 800-662-HELP (4357).
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The Tragic Toll of Police Work https://www.stress.org/news/the-tragic-toll-of-police-work/?utm_source=rss&utm_medium=rss&utm_campaign=the-tragic-toll-of-police-work Wed, 16 Apr 2025 13:27:11 +0000 https://www.stress.org/?post_type=news&p=110206 This article is from the Spring 2025 edition of Combat Stress magazine.

By Joseph Pangaro, CPM, CSO, MOI, LT (RET) 

Having served my community for 27 years, I have come to some understanding about this career in law enforcement and the things we do. Our profession calls on us to be calm during a storm, the voice of reason in unreasonable situations, and the emotionless authority that makes things better. These are high ideals for mortal men and women. 

The Observers of Society 

From the time we graduate from the police academy, we are advised that we simply are observers of happenings. We are not personally involved in the events we encounter. We are told that the horrific scenes and the destruction of people’s lives we witness are part of the job. The pain and suffering we see people living with are not our pain and suffering. Don’t take it home with you. Forget about it. Ignore it. 

That sounds easy until you are called on to tell a wife that her husband was killed in a senseless car accident; to watch helplessly as a mother cries over the dead body of her drug-addicted child; or to see precious, innocent children abused by the adults in their lives. We as law enforcement personnel have to witness and live with such terrible situations every day. We are taught to push these images out of our minds and leave them at work. The culture of law enforcement encourages us to believe that we can just move on from these things, but I don’t think it really works that way. I believe that these default positions build up and take a toll on us over the years. They wear us down emotionally. 

The Effects of Policing 

I point to the sobering statistics of law enforcement suicide. Every year in the United States, criminals kill between 100 and 150 of us. (1) This is a staggering reality and a tragic part of our job. What is worse, though, is that we kill ourselves at twice that rate, almost 300 police suicides a year. (2) That is higher than any other profession, and there is a reason. I believe that reason is the common practice of moving through the painful, emotionally draining situations we face every day and trying to ignore them. We are tough. Those things don’t bother us. Right? 

Cop humor is famous in our circles. The things we say and the jokes we make at some of the scenes we end up at would leave the people outside our profession speechless. If they heard some of the comments and wisecracks, we make, they would ran out of the room screaming, convinced that we were crazy. Cops, however, know that this humor is not callousness. It is a way to deal with the things we encounter and a way to have control over what we cannot fix or make better. The key here is understanding that this dark humor is a coping mechanism, not a “dealing with it” mechanism. These two expressions are extremely different and so is the emotional truth of the situation. It is between these two phrases and the real-life places we live that can damage us, not as cops but as people. 

The Concept of Compassion 

This is where the concept of compassion and understanding of how it fits into our lives must come into play. The compassion I am talking about is not simply feeling sorry for someone or being upset that they are in a predicament. Rather, it is an all-encompassing emotion that has attendant actions. For our own good, we must seek out this compassion to help us not just live through these difficult situations but to survive them over the long haul. 

One way to foster compassion is to see people for who they are, regardless of why they have come into our lives. Developing compassion for all of the people we encounter should be a goal. Extending it to the victims we deal with is not difficult. They deserve our attention and priority. But, for the “bad guys,” extending our compassion often can prove challenging. These people usually do not engender our warmest thoughts. It is here, however, that we can try to change our thoughts and actions. First of all, it is the decent thing to do; after all, we are the guardians in any given situation. Treating defendants with compassion helps reveal the decency within us. People end up in unfortunate situations for many reasons. Admittedly, most of them of their own doing but, sometimes, just because of problematic lifestyles. That does not excuse them of their actions; we all have to be accountable for our choices. My point here is simply that some people have made ill-fated choices based on the hand they were dealt with. Anyone can find themselves in a difficult spot at some point in their lives. We all know people like this, and some of us have those people in our own families. Treating such people with dignity and compassion speaks more about us than them. 

Next, and most important, we must be compassionate toward ourselves. We must change the culture of law enforcement that ignores the emotional scars the job can leave on our souls. We must address these situations, accept the horror of them, and talk about how they can affect us. We are not too tough to be moved by the death of a child or the collapse of someone’s life. The purpose of this self-compassion and facing the terrible things we see is not to make us touchy-feely cops or to get in touch with our nurturing sides but, rather, to help us address the negative feelings that come with the experiences we have. Once we deal with these feeling head-on, we can put them into perspective, which will take away their power over us. It is only then that we can move on without damage. 

Our career provides us with an unprecedented glimpse into the world of human interaction. It is a double-edged sword, though. On the one hand, we have a “backstage pass to life;” we see things and go places that most people only hear or read about. On the other hand, we sometimes have to conduct our business in the depths of people’s cruelty to each other. It is an honor to be in law enforcement and a great trust the people of our society have given us. We must not allow the rigors of the work and the fact that we are placed into some extremely difficult situations to deprive us of the joy this life has to offer. By making these changes in our police culture, perhaps we can save some of our 300 brothers and sisters who die by their own hand each year. 

Conclusion 

After 27 years on the job, I have made my peace with the evils people do to each other. The idealistic beliefs of my youth have matured over time. I have come to accept the fact that I cannot save the whole world, but what I can do is make small differences in the lives of the people I encounter. In this way, I help them and take care of myself. We all need to take care of the person inside. All of the officers who have killed themselves call out to us. We must listen and learn from them. We must start a dialogue that is long overdue. 

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Stress Without Borders: The Emotional Toll of Operation Lone Star on Troops and Their Families https://www.stress.org/news/stress-without-borders-the-emotional-toll-of-operation-lone-star-on-troops-and-their-families/?utm_source=rss&utm_medium=rss&utm_campaign=stress-without-borders-the-emotional-toll-of-operation-lone-star-on-troops-and-their-families Mon, 07 Apr 2025 16:03:37 +0000 https://www.stress.org/?post_type=news&p=109862 This article appears in the Spring 2025 edition of Combat Stress Magazine.

By Miguel Ruiz, Marketing Strategy Director 

In an election year, various public interest and political topics and rhetoric arise in droves. Turn on any station, click any story, and you’re sure to be flooded with various narratives that all seem designed to pit you against another side. One of those persistent issues is the state of the U.S. southern border. For the past several years, the media has brought constant news from that region. But here’s the thing: seldom do you hear stories from the level of the people working at the border. Nowadays, independent journalism and social media platforms have helped surface some of these stories, but most major news outlets still don’t cover the ground-level experiences. Instead, they may emphasize rhetoric and talking points. 

The fact is that multiple governmental and local agencies partner together 24/7 to combat the everyday challenges along the southern border. I won’t get into the broader issues themselves because that’s for another platform and deserves a much more detailed explanation. But instead, I want to shine a light on the people working the border. You’ve got dozens of sheriff’s departments, police departments, state entities, federal entities, and then you also have the Texas Military Department — specifically, the Texas Army National Guard. I was one of those Texas Army National Guard troops, part of the first Texas boots on the ground in the currently ongoing Operation Lone Star, the Texas-backed mission to deploy Soldiers and state troopers to support overwhelmed local agencies along Texas border cities. 

For National Guardsmen, deployment can be wildly unpredictable, unlike active-duty military personnel who often have months of notice and lead-up training before deployment. Statewide deployments for Guardsmen typically come at the last minute, following orders directly from the governor. In my first year as a Guardsman, I was working full-time in a sales office in Fort Worth, a regular post-college gig. One day, I got a call at my sales desk from my unit commander telling me I was deploying that night and needed to pack my gear immediately to commute to a Guard airfield hours away. This was to participate in 24-hour flood rescue operations in the Rio Grande Valley for an uncertain period of time. Thankfully, my employer was Guard-friendly and understood my obligations, but this abrupt change of routine was something I would grow accustomed to over the next six years. As my life evolved, so did the stakes — what started as manageable disruptions when I was single turned into much greater challenges as I started a family, including numerous sudden activations for stateside disasters and then Operation Lone Star. 

For me, that deployment happened less than two years ago. I served as a 46S, a Public Affairs Mass Communication Specialist, in charge of other Public Affairs Soldiers and responsible for setting up journalism operations along the entire border. I had a unique backstage view into everything — from planning operations, logistical movements, and intelligence, to being on the ground, rolling around with first responder agencies in my own sanctioned vehicles, and participating in various, and uniquely dangerous, operations. 

What makes deployments for Texas Army National Guard Soldiers unique is that most of them, myself included, have full-time civilian careers back home. Most National Guard troops receive abrupt orders to deploy in response to natural disasters, civil unrest, or in this case, Operation Lone Star — an unprecedented activation of state Soldiers and law enforcement officers, with political implications and controversies. 

The financial and logistical challenges associated with Operation Lone Star became a significant point of controversy, drawing public criticism and political debate. As a public affairs non-commissioned officer (NCO), I was tasked with coordinating my small unit of Soldiers, scattered across the border, ensuring their pay, lodging, responsibilities, and personal affairs were handled. But just weeks into our sudden deployment, several of my Soldiers went without pay for months. One had a mortgage and child support to manage, dipping into savings multiple times to stay afloat. Another Soldier I overheard in line at the headquarters pay office was pleading for immediate pay, explaining how his wife was a stay-at-home mom, and they had missed bills, creating a dire financial situation. It was a morale killer for many of the troops, especially when such a basic need like pay wasn’t met, creating immense stress not just for the Soldiers but also their families. 

Stress was rampant throughout the operation, for both the National Guard and other first responders. While I could handle the physical and emotional toll as part of the job, it was the prolonged uncertainty that really wore me down. My original orders were for a four-month deployment, but as time passed, those orders extended — first to eight months, then 12, and eventually, there was no clear end in sight. For someone like me, who had a family at home and a baby on the way, this uncertainty became an additional source of stress. How do you tell your family or civilian employer when you’re coming home when you don’t even know yourself? I had that conversation with my spouse and family over and over: “I don’t know when I’m coming home.” 

The stress I experienced during my time in the National Guard was expected in many ways — I signed up knowing military operations, whether local or global, came with challenges. But there were things you don’t anticipate, like the loss of close friends and colleagues in various missions, or the prolonged uncertainty and separation from family during back-to-back deployments. These experiences deeply affected me, my fellow Soldiers, and our families. Now, as I’ve transitioned to full-time civilian life and a career in marketing, I realize how much those past stressors prepared me. Today, I find myself able to handle high-pressure situations with a certain calmness — or perhaps a numbness. Whether that’s a good thing or not, I’m still unsure, but at least it taught me resilience and an ability to multitask and endure challenges in both my personal and professional life. 

Despite all this, we carried on and completed our portions of the mission, even in the face of deadly working conditions during some of the operations. The irony is, while Soldiers and first responders were dealing with these immense challenges, much of the media focused on political controversies or big headlines. Rarely did anyone speak about the toll on the ground level — on the Soldiers, law enforcement, or even the migrants facing life-changing stress, with families torn apart and lives lost at the border. 

In the end, I simply want to shed some light on the brave first responders and Texas Guardsmen who continue to serve along the southern border, away from their families, in extremely difficult conditions. The next time you hear someone repeat political talking points, I hope you also think about the human side — the men and women who serve every day, often unseen, under immense stress. 

 

Miguel Ruiz is a marketing and advertising professional with over 12 years of experience, leading marketing for clients across Texas and around the globe. A former Public Affairs Mass Communications Specialist in the Texas Army National Guard, Miguel documented multiple overseas deployments, humanitarian missions, and stateside operations. Beyond his professional endeavors, he serves on nonprofit boards in Fort Worth, mentors rising marketing professionals, and provides pro bono training for local small business owners. Named one of Fort Worth Inc.’s “40 Under 40,” Miguel is currently pursuing a Master of Science degree at Texas A&M University. He can be reached at mruiz@joagency.com. 

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Stress changes how we recall memories, making them seem frightening https://www.stress.org/news/stress-changes-how-we-recall-memories-making-them-seem-frightening/?utm_source=rss&utm_medium=rss&utm_campaign=stress-changes-how-we-recall-memories-making-them-seem-frightening Mon, 18 Nov 2024 15:39:50 +0000 https://www.stress.org/?post_type=news&p=106171 Every organ in the human body is extraordinary, but the brain is an organ that often surpasses our understanding. It determines how we perceive the world, how we act, and how we remember. Our brain is hard at work – day and night. Yet, the brain is more than just an information-processing center; it’s also the epicenter of our memories, emotions, stress, and fears.

Stress can lead to more than just a stiff neck or a racing heart. In extreme cases, it can influence our brain to create and retrieve memories in strange and unusual ways.

Researchers at The Hospital for Sick Children (SickKids) have made fascinating discoveries about the relationship between stress, memory, and our brains’ biological processes.

Stress and memory: Unsettling connection

Perhaps you’ve given a presentation that didn’t go as planned. The next time you’re due to present, you might feel stressed because your brain has linked this new presentation to the memory of the previous unsatisfactory experience. This is a type of stress tied to one memory.

However, stress from traumatic events, like witnessing violence or suffering from generalized anxiety disorder, can have a far-reaching impact. It can cause what is known as stress-induced aversive memory generalization.

Here, unrelated stimuli can trigger frightening memories that seemingly have no connection to the original traumatic event. This phenomenon can have severe consequences for individuals who suffer from post-traumatic stress disorder (PTSD).

Memories after stress

Dr. Sheena Josselyn and Dr. Paul Frankland, experts in the Neurosciences & Mental Health program at SickKids, have identified the biological processes that result in stress-induced aversive memory generalization.

The experts have also found a potential intervention that could help restore the specificity of memory in individuals with PTSD.

“A little bit of stress is good, it’s what gets you up in the morning when your alarm goes off, but too much stress can be debilitating,” said Dr. Josselyn.

“We know that people with PTSD show fearful responses to safe situations or environments, and have found a way to limit this fearful response to specific situations and potentially reduce the harmful effects of PTSD.”

Understanding the mechanics

In a collaborative effort with Dr. Matthew Hill from the University of Calgary Hotchkiss Brain Institute, the research team was able to limit stress-induced aversive memory generalization to the specific, appropriate memory. This was achieved by blocking endocannabinoid receptors on interneurons.

To understand this process better, the team set up a preclinical model. They exposed subjects to a small amount of stress before a distressing event. This created a generalized fearful memory that could be triggered by unrelated safe situations, mirroring how PTSD manifests in humans.

Upon inspecting the subjects’ memory engrams (the physical representations of a memory), the research team made an interesting discovery. Typically, engrams involve only a small number of neurons. However, the stress-induced memory engrams involved a significantly larger number of neurons.

When they examined these larger engrams more closely, the team found that stress resulted in increased endocannabinoid release in the brain, which disrupted the function of interneurons.

Formation of fearful memories

A significant bit of the puzzle lies in a previously overlooked area – the endocannabinoid system. This system plays a key role in forming memories and associating experiences with specific behavioral outcomes.

Special “gatekeeper” interneurons in the amygdala, the emotional processing center of the brain, help constrain the size of the engram and, therefore, the specificity of the memory.

When too many endocannabinoids are released, these gatekeeper interneurons cannot function properly, leading to an increase in the size of the engram.

“Endocannabinoid receptors function like a velvet rope at an exclusive club. When stress induces the release of too many endocannabinoids, the velvet rope falls, causing more generalized aversive fearful memories to form,” explained Dr. Josselyn.

“By blocking these endocannabinoid receptors just on these specific interneurons, we could essentially prevent one of the most debilitating symptoms of PTSD.”

Stress-induced memory engrams

In 2023, previous research published in the journal Science identified larger, more generalized memory engrams in the developing brain than in the adult brain, similar to stress-induced memory engrams.

As the experts continue to explore this unexpected connection between engram size, stress, and age, they also aim to understand how daily stressors might affect positive memories.

“The many biological functions and processes that make up the complexity of human memory are still being uncovered,” said Dr. Frankland.

“We hope that as we better understand human memory, we can inform real-world therapies for those with various psychiatric and other brain disorders throughout their lifespan.”

Indeed, as our understanding of the human brain continues to expand, so too do our hopes for revolutionary treatments and therapies. Through the diligent work of these researchers and others in the field, we may be able to fully unravel the mysteries of the brain, stress, and memory.

The study is published in the journal Cell.

For more information about STRESS-RELATED issues go to stress.org

 

OP-earth.com

Earth.com staff writer
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Facing Fears: Patients With Past Trauma Can Still Enjoy Halloween https://www.stress.org/news/facing-fears-patients-with-past-trauma-can-still-enjoy-halloween/?utm_source=rss&utm_medium=rss&utm_campaign=facing-fears-patients-with-past-trauma-can-still-enjoy-halloween Wed, 09 Oct 2024 15:36:38 +0000 https://www.stress.org/?post_type=news&p=105346 Just because a patient has anxiety or past trauma does not mean they cannot enjoy this spooky holiday…

Q&A

Happy Halloween! While this holiday can be filled with tricks and treats, it can also be difficult for patients with anxiety or a history of trauma. How can you as a clinician guide them towards enjoyment rather than fear?

PT: How do you think Halloween impacts patients with high anxiety/stress levels?

Anderson: For many, kids and adults alike, Halloween is an exciting, fun-filled time of the year. It is accompanied by parties, candy, cakes, drinks, and scary movies. Dressing up in costumes allows individuals to try on another persona or become their favorite character for the day.

However, for many with anxiety, stress, or trauma, this holiday can be a nightmare. Those who suffer from panic or posttraumatic stress disorder (PTSD) symptoms (intrusive images, increased anxiety, an exaggerated startle response, increased heart rate and breathing, alternating with numbness, avoidance, disconnection, and dissociation), can find Halloween grueling and intolerable to partake in. Being spooked or intentionally scared can be terrifying for someone with a trauma history, it can trigger panic attacks, cause increased heart rate, and activate traumatic memories from the past.

PT: Should patients with past trauma avoid scary movies/haunted houses? Why?

Anderson: My suggestion for those struggling with anxiety or have a history of trauma is to avoid scary movies and haunted houses all together. They can activate symptoms of panic, PTSD, and cause traumatic memories from the past to resurface. Reliving traumatic experiences re-enforces trauma neural networks in the brain and can be taxing on one’s physical and mental health. It causes distress, fear, isolation, numbness, a lack of feeling safe, and even can trigger suicidal feelings.

PT: Research shows that women are more likely than men to be interested in consuming true crime stories.1 Some suggest this is because women experience catharsis from content like this. Do you think that is true? How much true crime is too much?

Anderson: It is important to be aware that this research presents one such perspective as to why women read true crime stories. Many women avoid reading them altogether because they are too activating for them. One possible explanation for this desire, however, is that there is an element of mastery for those women who choose to consume true crime movies. Some of the stories are solved or resolve favorably in the end. This could bring hope or justice or a sense of control to an otherwise difficult and hopeless situation. Watching or reading about someone else’s experience without going through it directly, could bring a sense of comradery or belonging for some women who feel alone in their experience.

PT: Is there any truth behind the concept of “facing our fears”?

Anderson: Most of the research that supports “facing one’s fears,” is conducted when subjects are feeling in control of their situation, and does not incorporate the element of surprise. It is never forced upon someone and ensures that individuals feel agency about the pace and intensity of the exposure to the overwhelming situation in question. Those who watch crime stories repeatedly sometimes use it to access repressed or dissociated feelings they normally do not have access to. This, however, is not generally recommended by professionals as a useful method of working through one’s traumatic past.

PT: How can patients enjoy Halloween without triggering memories of past traumas?

Anderson: The best way to enjoy Halloween is to be in control of the exposure to scary, deceptive, or frightening events. Many trauma survivors dislike the holiday all together and choose to not participate in it because it commonly brings forth unwanted symptoms from their past. One way to move through the holiday with more ease and levity is to experience it through the eyes of children. Focus on the fun, the innocence, the joy of the holiday, compared to what adults tend to focus on: the horror, the deception, and the jump scares. Halloween can be enjoyable when it does not reflect or trigger one’s trauma or anxiety from the past.

To learn more about stress go to STRESS.ORG

Photo by Rahul Pandit

Dr Anderson is a psychiatrist, trauma specialist, and author of the upcoming memoir To Be Loved: A Story of Truth, Trauma, and Transformation (PESI, May 7, 2024).

OP-Psychiatric Times

By Author(s): Leah Kuntz and   Frank G. Anderson, MD

Reference

1. Vicary AM, Fraley RC. Captured by true crime: why are women drawn to tales of rape, murder, and serial killers? Social Psychological and Personality Science. 2010;1(1):81-86.

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Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study https://www.stress.org/news/exaggerated-amygdala-response-to-masked-facial-stimuli-in-posttraumatic-stress-disorder-a-functional-mri-study/?utm_source=rss&utm_medium=rss&utm_campaign=exaggerated-amygdala-response-to-masked-facial-stimuli-in-posttraumatic-stress-disorder-a-functional-mri-study Mon, 22 Jul 2024 16:14:45 +0000 https://www.stress.org/?post_type=news&p=89250
Affiliations 

Affiliation

  • 1Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA.

Abstract

Background: Converging lines of evidence have implicated the amygdala in the pathophysiology of posttraumatic stress disorder (PTSD). We previously developed a method for measuring automatic amygdala responses to general threat-related stimuli; in conjunction with functional magnetic resonance imaging, we used a passive viewing task involving masked presentations of human facial stimuli.

Methods: We applied this method to study veterans with PTSD and a comparison cohort of combat-exposed veterans without PTSD.

Results: The findings indicate that patients with PTSD exhibit exaggerated amygdala responses to masked-fearful versus masked-happy faces.

Conclusions: Although some previous neuroimaging studies of PTSD have demonstrated amygdala recruitment in response to reminders of traumatic events, this represents the first evidence for exaggerated amygdala responses to general negative stimuli in PTSD. Furthermore, by using a probe that emphasizes automaticity, we provide initial evidence of amygdala hyperresponsivity dissociated from the “top-down” influences of medial frontal cortex.

Photo by Anna Shvets

Post PubMed

 

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Innocence Project’s Re-entry Coach and Exoneree Rodney Roberts Shares 6 Tips to Reduce Stress https://www.stress.org/news/innocence-projects-re-entry-coach-and-exoneree-rodney-roberts-shares-6-tips-to-reduce-stress/?utm_source=rss&utm_medium=rss&utm_campaign=innocence-projects-re-entry-coach-and-exoneree-rodney-roberts-shares-6-tips-to-reduce-stress Fri, 12 Jul 2024 15:29:08 +0000 https://www.stress.org/?post_type=news&p=89222 Having spent 18 years behind bars for a crime I didn’t commit, I know firsthand the toll a wrongful conviction can take on one’s mental well-being.

An exoneration is a joyful experience for someone who has been wrongfully convicted. Yet for all the joy and celebration, exonerees may confront deep and emotional mental health struggles stemming from incarceration

Having spent 18 years behind bars for a crime I didn’t commit, I know firsthand the toll a wrongful conviction can take on one’s mental well-being. Wrongful convictions shatter lives, leaving scars that aren’t always visible. In my role as Innocence Project’s first-ever re-entry coach, I am dedicated to helping exonerees find their paths to healing and resilience as I navigate my own. 

Here are some coping mechanisms that have helped me and others navigate the complexities of incarceration and life after exoneration that may be helpful to others.

Rodney Roberts

Rodney Roberts out for a bike ride. (Image: Courtesy of Rodney Roberts)

1. Get active.

It’s common knowledge that regular exercise, like daily walks or workouts, is good for our physical health, but regular body movement is essential for reducing stress that could lead to depression. These activities provide a space for release, allowing us to channel our energy positively. 

I engage in physical activities like bike-riding and Tai Chi to not only promote my physical health but also nurture my mental well-being. Similarly, Innocence Project client Norberto Peets, who was wrongly incarcerated for 26 years, has shared how basketball served as an outlet to channel stressful energy.

“In Sing Sing Prison, I played basketball all day, and it helped me stay in good shape, but, in that moment when I was playing basketball, it took a lot of stress away from me,” he explained after his release in 2023. “That was the only time I felt like I was a little free and not so in my mind about all the stuff I was dealing with.”

Marvin Anderson on his front lawn at his home in Virginia. (Image: Courtesy of Marvin Anderson)

Marvin Anderson on his front lawn at his home in Virginia. (Image: Courtesy of Marvin Anderson)

2. Connect with nature. 

Gardening offers a sense of purpose and tranquility. Tending to plants, nurturing their growth, and witnessing the beauty of the natural world can be profoundly healing, providing a grounding presence amidst the chaos of post-exoneration life.

Marvin Anderson, an exoneree and a member of the Innocence Project’s board of directors, began cultivating plants at an early age, helping out on his family’s farm. He rediscovered this passion after he was released in 1997 on parole — he was later exonerated in 2002. 

“A lot of people think gardening is really hard work and very complicated, but I find it very relaxing, and it’s easier than you think,” Mr. Anderson said in 2021.

To learn more about stress and stress-related issues go to stress.org.

Photo by RDNE Stock project

By Rodney Roberts for  Innocence Project

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Targeting PTSD’s Inflammatory Biomarkers: Resolving Inflammation with Nutrition-Based Nitric Oxide Supplementation https://www.stress.org/news/targeting-ptsds-inflammatory-biomarkers-resolving-inflammation-with-nutrition-based-nitric-oxide-supplementation/?utm_source=rss&utm_medium=rss&utm_campaign=targeting-ptsds-inflammatory-biomarkers-resolving-inflammation-with-nutrition-based-nitric-oxide-supplementation Sat, 29 Jun 2024 15:42:15 +0000 https://www.stress.org/?post_type=news&p=89176 This article appeared in the Spring 2024 edition of Combat Stress magazine.

By Stanford A. Graham, JD and Judy Mikovits, PhD 

Introduction 

Neurological dysfunctions are a profound health burden among Veterans, disrupting and debilitating their lives.1 These dysfunctions are often caused by trauma. Consistent with the variety of ways trauma is experienced, neurological dysfunctions are also a varied complex of biological system dysregulation.2 Unfortunately, even the U.S. Department of Veteran Affairs (VA) describes these neurological conditions within the unhelpful category of “mental health problem[s].”3 

Fortunately, decades of research are slowly pealing back the layers of these disruptive dysfunctions and their causal complexities. We are learning that neurological dysfunctions are intimately connected with other malfunctioning body systems in a variety of ways. Moreover, recent science is also showing that, at a cellular level, these multi-system dysfunctions also share similar neurological pathways. For example, PTSD is experienced via pathways that are common to substance abuse, diabetes, arthritis, and Alzheimer’s disease.4 Would it surprise you to learn that PTSD symptoms regularly occur contemporaneously with chronic inflammatory symptom conditions such as obesity, type 2 diabetes, insulin resistance, chronic pain, sexual dysfunction, and cardiovascular disease?4-7 A 2020 study published in Translational Psychiatry emphasized our more complete understanding of neurological dysfunctions this way: “PTSD is no longer classified among anxiety disorders; it is considered a trauma or stressor-related disorder… Because of the marked impact of stressors on the immune system, it is not surprising that PTSD is associated with the immune state. Increased concentrations of pro-inflammatory factors were observed both within systemic circulation and in the brain in the context of PTSD… highlighting a close link between inflammation, stress, and PTSD.6 In fact, the more inflammation we experience, the more severe PTSD symptoms become.7 

In short, neurological disorders are causally intertwined with immune system dysregulation and its consequent impact on many other biological systems,6 including the cardiovascular and nervous systems, the digestive, circulatory,8 and the hepatic and endocrine systems, to name a few.4 These multi-system malfunctions induce recurring cell-level dysregulation as well, including redox stress, disruption of telomere homeostasis, mitochondrial activity, vitamin D activation, and endothelial nitric oxide (NO) production.9,10 These factors cause us to age more quickly, to lose our ability to metabolize our food, negatively affect our ability to think and sleep, and decrease our ability to recover from injury and illness. All these issues weaken the brain and body, making us more susceptible to illness and infection.10 

What are these “pro-inflammatory factors” that link chronic inflammation, stress, and PTSD?  They are molecules produced by a dysregulated immune system. They inflame the body, its organs, blood, and tissues, including precise brain regions. They commonly proliferate in groups, including this particular set in PTSD cases: interleukin-1 (IL-1β), interleukin-6 (IL-6),1 tumor necrosis factor (TNF-α), interferon (INF-ץ), and C-reactive protein (CRP).7 This same cytokine group is not only at the heart of PTSD, but at the foundation of XMRV, COVID 19, and Acquired Immune Deficiency/Dysfunction. Indeed, these cytokines are the biological origins of both body and brain disease and dysregulation.5

So, the question becomes how can the chronic production of these dangerous cytokines be naturally decreased while simultaneously fortifying and increasing human health? The available data suggest that targeting chronic inflammation “may serve as a potential therapeutic target for treating neuroimmune disease.”4 The good news is that there is both hope and progress. Recent research is exploring ingredient-complex nutraceuticals that act systemically throughout the human body to target these bad-acting molecules while supporting cell health.9 

Comprehensive research analysis reveals that a deficiency of the amino acid L-arginine (“arginine”) is a primary contributor to chronic inflammation and neuroimmune diseases.11 So, now you likely have a few questions:  What is arginine and how can you safely get what your body needs? What functions does arginine help your body perform to reduce inflammation? What is the relationship between arginine and NO production, and how does NO support vibrant health?10 

What is Arginine? 

Arginine is a non-essential amino acid, meaning under optimal conditions, the body can produce its own supply. It is derived from body protein breakdown or endogenous de novo arginine production in the kidneys.11 When cells are healthy, they also synthesize arginine from the amino acid L-citrulline (“citrulline”).10 However, when cells are under catabolic stress or trauma, the body’s arginine requirements dramatically increase to help address and resolve injuries and improve biological and neurological functions. Therefore, during injury and healing periods, arginine must be obtained from food intake, making arginine “conditionally” essential.11 Arginine is abundant in seeds, nuts, meats, seafood, and soy protein isolate. Yet, despite arginine’s seemingly high availability in non-genetically modified foods, the fluctuating rate at which the human body uses arginine influences its bioavailability and likely deficiency.12,13 For example, the small intestines and kidneys collaborate in the whole-body synthesis of arginine.14 Consequently, when these organs are dysregulated or injured, arginine deficiency is inevitable. This emphasizes the general need for nutrition-based arginine supplementation.15  

Arginine’s Function and Purpose 

Arginine plays a vigorous and versatile role in the human body. It is necessary for cell division, immune system function, ammonia disposal, reparative response to trauma, and wound healing.16 It also supports hormone biosynthesis, including stimulating the release of insulin, growth hormone, and endogenous production of vitamin D3.9 Arginine is also necessary for T-cell maturation and activation. One of arginine’s most important functions is nitric oxide production. Arginine is the sole fuel specialized cells use to make nitric oxide, often referred to as the “miracle molecule.” Those specialized cells are called endothelial cells. They compose the interior lining of the entire vascular system.17 NO is a primary signaling molecule that facilitates hundreds of cellular, organ, and biological system functions. This is why arginine deficiencies inevitably result in NO deficiencies. In turn, NO deficiencies invariably lead to immune system dysfunction, blood dysregulation, and the spiraling proliferation of dangerous cytokines and inflammatory diseases, including PTSD.   

PTSD and Global Arginine Bioavailability Ratio 

Recent research shows that solving arginine deficiency and inadequate NO production helps resolve PTSD symptoms and associated inflammation-caused comorbidities.10 In 2016, an international research team was the first to measure arginine levels in Veterans with PTSD who had inflammatory levels of IL-1β, Il-6, TNFα and IFNץ.10 Their purpose was to explore the causes of, and possible new therapeutics for, neurological and biological aspects of PTSD.7 The team discovered a surprising and direct connection: The inflammatory molecules proliferated when the Veterans had low blood serum levels of arginine. With this observation, the team’s understanding of PTSD expanded “from a purely mental illness to an illness with important somatic manifestations” which could “lead to novel treatment options for both the psychiatric and somatic aspects of the condition.”7 

The research team called their diagnostic tool the “global arginine bioavailability ratio” (GABR). This ratio identifies the amount of bioavailable arginine in blood serum compared to the combined amounts of two other amino acids, ornithine and citrulline. The research team found that higher levels of bioavailable arginine, with consequent higher levels of bioavailable NO, predictably resulted in lowered PTSD symptom severity. They emphatically concluded: “The present study provides the first evidence that the global arginine bioavailability [ratio], a marker of NO synthetic capacity in vivo, is decreased in Veterans with PTSD and is negatively associated with markers of inflammation as well as with measures of PTSD symptom severity.”7 In short, Veterans with PTSD symptoms were experiencing arginine and NO deficiencies. Thus, increasing both arginine and NO bioavailability decreased inflammatory bio-marker levels and PTSD symptom severity.  

Nitric Oxide and its Functions 

As previously stated, endothelial cells are the engine of endothelial NO production. NO creates both good outcomes and prevents bad ones. First, adequate supplies of NO regulate and optimize blood flow, blood viscosity, blood speed, blood oxygenation, vessel flexibility, insulin production, cell cleansing (autophagy), and much more. Additionally, NO maintains the cleanliness of blood vessels, blocking adhesion of blood platelets, lipids, bacteria, and other matter to the inner vascular wall. Hence, NO helps prevent strokes, unwanted blood clotting, hypoxia, and inflammation.10 NO deficiency, on the other hand, leads to strokes, atherosclerosis, and the proliferation of oxidative reactive oxygen species (“ROS”) throughout the body. In fact, NO deficiency is also the common denominator of many chronic inflammatory diseases, including hypertension, diabetes, aging, heart attack, Alzheimer’s disease, Parkinson’s disease, epilepsy, migraine, and other neurodegenerative diseases.10 Maintaining healthy NO production is, therefore, key to sustained functional health. So, how do we prevent NO deficiency? 

Mechanisms of Arginine and Nitric Oxide Deficiency 

Arginine deficiency is created in two major ways. First, it results from an unhealthy diet. Second, stress, trauma, and inflammation cause the over-production of arginase, an enzyme that ravenously consumes arginine, resulting in too much ornithine.18 “Overly active arginase can reduce the supply of arginine needed for the production of NO, leading to an over-supply of ornithine. Too much l-ornithine can lead to structural problems in the vasculature, neuronal toxicity, and abnormal growth of tumor cells.”18 An increase in ROS and inflammatory molecules promote pathological elevations of arginase activity. 

Arginine metabolism by arginase, which lowers NO production in PTSD sufferers, is a function of commonly experienced and repeated fact patterns in the lives of Veterans: 

  • Physical trauma, including battle wounds involving bullets, bombs, shrapnel, burns, broken bones, tissue damage, critical illness including bacteria, viruses, infection, and prolific pro-inflammatory concentrations;11 
  • Psychological trauma, including seeing and hearing death, social destruction, profound injuries to humans, observing, and participating in intense human suffering;11 and  
  • Invasive medical treatment and recovery, including blood transfusions and ion radiation.17 

For example, wounds, whether physical or mental, require higher amino acid levels to heal.11,17 Typically, all Veterans have inadequate levels of global arginine during wound and healing periods.11 Thus, their NO levels are also reduced, prolonging the healing process. 

Next, infection is a tremendous biological and neurological stressor via the immune system. Approximately 10% of all trauma patients develop wound infections. Infection rates soar to 30% in those who remain in the ICU for over 48 hours. Tragically, infections are the leading cause of late organ failure and contribute up to 10% of all trauma-related deaths.11 Infection also reduces already low levels of arginine thereby decreasing NO production and compromising the healing process. 

Additionally, blood transfusions cause arginine and NO deficiencies. A 2011 study found that blood transfusions impair NO production and cause endothelial dysfunction.” Moreover, stored red blood cells (“RBC”) cause the accumulation of free hemoglobin that consumes NO at a rate 1,000 times faster than when it is bound within healthy RBC. Hemolytic RBC’s also releases arginase, causing substantial reductions in intravascular arginine.19 The result?  Drastically decreased arginine, decreased NO and increased vascular damage.13 

Next, ionizing radiation in the form of CT scans, PET scans, and x-rays  immediately injures endothelial cells. This compromises NO production while simultaneously causing the proliferation of IL-1, IL-6, TNF-α and TGF-B, the very causes of PTSD symptoms.20 

The final mechanism of NO deficiency is a molecule called superoxide. When the body makes NO it inevitably creates superoxide. When NO and superoxide combine, they form a new molecule called peroxynitrite, considered “one of the most destructive molecules in the biological milieu.”10 Hence, helping the body create healthy NO while simultaneously reducing peroxynitrite formation is imperative for healing, sustained health, and vitality. 

This brief list demonstrates the catastrophic health consequences that can occur during common medical procedures, in addition to the those caused by the trauma being treated. These fact patterns emphasize the need for supplementing arginine in a healthy and thoughtful way, with proven nutrition-based supplements. These scientifically proven products can safely increase bioavailable arginine and long-term NO production while reducing peroxynitrite production. Perhaps most importantly, proper arginine supplementation can help Veterans reduce the inflammatory agents that manifest in PTSD symptoms. 

Erectile Dysfunction 

One final disorder associated with PTSD that warrants our attention is erectile dysfunction (ED). Research shows that ED is an expression of relational, psychological, and biological components.21 It is associated with aging and PTSD systemic comorbidities like cardiovascular disease (CVD), hypertension, diabetes, and depression. Smoking, alcoholism and drug abuse are related behaviors. If you suffer with ED, you are not alone.  It afflicts 25% of men younger than 59 and 61% of men over 70.22 

Research also reveals that “NO is the primary biochemical mediating erectile function.” Thus, we know that endothelial dysfunction, low NO production and minimal NO release are the chief mechanisms of organic ED.22-24 So what can you do? Supplement wisely with an arginine-based nitric oxide supplement. Studies show that arginine-derived NO is a vasodilator that controls systemic and penile blood flow and plays a singular role in erectile function.25 Studies have shown that arginine-induced NO boosts desire and sexual arousal, thereby increasing libido. It also relaxes “the smooth muscles in the genital area, allowing for increased blood flow and heightened sexual pleasure.”26 Supplementing with NO can improve your relationships, health, and mental well-being. 

New Therapeutic Models and Solutions – Cardio Miracle 

The need for nutrition-based solutions that target inflammatory molecules is clear.7 Fortunately, recent studies not only support these conclusions, but also demonstrate their existence and application. When testing a NO supplement product called Cardio Miracle (CM) in their nanotechnology lab at Ohio University, researchers found that 6 grams of its amino acid complex, including arginine, when consumed together with specific mixtures of over 40 anti-inflammatory and antioxidant foods, not only induced long-term production of bioavailable NO, but also significantly downregulated peroxynitrite production.10 

In 2022, ground-breaking research focused on the same NO supplement, CM. That study showed that long-term production of NO activated vitamin D3 production in the body. This biological process was previously unknown. In addition, the study revealed that CM’s specific formula down-regulated the specific group of pro-inflammatory cytokines associated with PTSD symptoms.9 This research directly supports the conclusions reached in the GABR research: Targeting inflammation with nutrition-based products can resolve underlying inflammatory causes and reduce the biological consequences and symptoms associated with PTSD and other neurological dysfunctions. 

In conclusion, Cardio Miracle helps maintain healthy, systemic arginine levels, supports long-term endothelial nitrous oxide production, and down-regulates peroxynitrite and the specific group of pro-inflammatory cytokines associated with PTSD symptom severity. Accordingly, supplementation with Cardio Miracle should be seriously considered in ameliorating the negative neurological and biological dysfunctions associated with PTSD and associated injuries suffered by Veterans, their friends, and families.  

References 

  1. Kim, S.Y., Yeh, PH., Ollinger, J.M. et al. Military-related mild traumatic brain injury: clinical characteristics, advanced neuroimaging, and molecular mechanisms. Transl Psychiatry. 2023,13:289. 
  1. Bhatt, S., et al. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies. Nat. 2020, 11(1):2360. 
  1.  PTSD Basics – PTSD: National Center for PTSD. https://www.ptsd.va.gov/understand/what/ptsd_basics.asp  
  1.  Michopoulos, V., Powers, A., Gillespie, C.F., Ressler, K.J., Jovanovic, T.  Inflammation in fear and anxiety-based disorders:  PTSD, GAD, and beyond.  Neuropsychopharmacology. 2017, 42(1): 254-270. 
  1.  Tursich, M., et. al. Association of trauma exposure with pro-inflammatory activity: A transdiagnostic meta-analysis. Transl Psychiatry. 2014, 4(7):e413. 
  1.  Steardo, L. Jr., Steardo, L., Verkhratsky, A. Psychiatric face of COVID-19. Transl Psychiatry. 2020, 30;10(1):261.  
  1.  Bersani, F.S., et al.  Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation. Brain, Behav and Immun.  2016, 52:155.  
  1.  Ghiadone, L., et al. Mental Stress Induces Transient Endothelial Dysfunction in Humans. Circulation. 2000, 102(20):2473-2478. 
  1. Fliri, A.F., Kajiji, S. Functional characterization of nutraceuticals using spectral clustering: Centrality of caveolae-mediated endocytosis for management of nitric oxide and vitamin D deficiencies and atherosclerosis. Front  Nutr. 2022, 9. 
  1. Dawoud, H., Malinski, T. Vitamin D3, L-crginine, L-citrulline, and antioxidant supplementation enhances nitric oxide bioavailability and reduces oxidative stress in the vascular endothelium – clinical implications for cardiovascular system. Phcog Res. 2020, 12:17-23. 
  1. Morris, C.R., Hamilton-Reeves, J., Martindale, R.G., Sarav, M. and Ochoa Gautier, J.B.  Acquired amino acid deficiencies: a focus on arginine and glutamine. Nutrition in Clinical Practice.  2017, 32:30S-47S. 
  1. Morris, S.M. Jr. Arginases and arginine deficiency syndromes. Curr Opin Clin Nutr Metab Care. 2012, 15(1):64-70. 
  1. Benites, B.D., Olalla-Saad, S.T. An update on arginine in sickle cell disease. Expert Rev. Hematol. 2019, 4:235-244. 
  1. Marcel, C.G., van de Poll, Soeters, P.B., Deutz, N.E.P., Fearon, K.C.H., Dejong, C.H.C.  Renal metabolism of amino acids: its role in interorgan amino acid exchange. The American Journal of Clinical Nutrition. 2004, 79(2): 185–197. 
  1. Luiking, Y.C., Poeze, M., Ramsay, G., Deutz, N.E.P. The role of arginine in infection and sepsis. 2005, 29(1S):S70-S74. 
  1.  Al-Koussa, H., El Mais, N., Maalouf, H., Abi-Habib, R., El-Sibai, M. Arginine deprivation: a potential therapeutic for cancer cell metastasis? A review. Cancer Cell Int. 2020, 20:150. 
  1. Wijerathne, H., et al. Mechanisms of radiation-induced endothelium damage: Emerging models and technologies. Radiother Oncol. 2021, 158:21-32. 
  1. Caldwell, R.W., Rodriguez, P.C., Toque, H.A., Narayanan, S.P., Caldwell, R.B. Arginase: A multifaceted enzyme important in health and disease. Physiol Rev. 2018, 98(2):641-665. 
  1. Donadee, C., et al. Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion. Circulation. 2011, 124(4):465-476. 
  1. Gottfried, K.L.D., Penn G, editorsInstitute of Medicine (US) Committee for Review and Evaluation of the Medical Use Program of the Nuclear Regulatory Commission. Radiation In Medicine: A Need For Regulatory Reform, 1996. 
  1. Kaabi, Y.A., Abdelwahab, S.I., Albasheer, O. Comprehensive Analysis of Global Research on Erectile Dysfunction from 2002 to 2021: A Scientometric Approach. Int J Gen Med. 2023,16:5729-5741. 
  1. Burnett, A.L. The role of nitric oxide in erectile dysfunction: implications for medical therapy. J Clin Hypertens . 2006 8(12 Suppl 4):53-62. 
  1. Bacon, C.G., et al. Sexual function in men older than 50 years of age: results from the Health Professionals Follow up Study. Ann Intern Med. 2003; 139:161–168. 
  1. Brunner, H., et al. Endothelial function and dysfunction. Part II: association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension. J Hypertens. 2005, 23:233–246. 
  1. Ahmad, A., et. al. Role of nitric oxide in the cardiovascular and renal systems. Int J Mol Sci. 2018. 3;19(9):2605. 
  1. Toda, N., Ayajiki, K., Okamura, T. Nitric oxide and penile erectile unction. Pharmacol Ther. 2005. 106:233–266. 

 

 

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